Farnesoid X Receptor Mediates Macrophage-Intrinsic Responses to Suppress Colitis-Induced Colon Cancer Progression

Investigators demonstrated that inflammation-induced epithelial abnormalities compromised FXR signaling and altered bile acid (BA)’s profile in a mouse colitis-associated colorectal cancer model. Further, gut macrophage–intrinsic FXR sensed aberrant BAs, leading to pro-inflammatory cytokines’ secretion, which promoted intestinal stem cell proliferation.