Fbxw7 Suppresses Carcinogenesis and Stemness in Triple-Negative Breast Cancer through CHD4 Degradation and Wnt/β-Catenin Pathway Inhibition

Researchers detected F-box and WD repeat domain-containing 7 (FBXW7) by immunohistochemistry in 80 triple-negative breast cancer patients. FBXW7 knockdown and overexpression in MD-MBA-231 and HCC1937 cell models were constructed.