Identification of a Highly Conserved Neutralizing Epitope Within the RBD Region of Diverse SARS-CoV-2 Variants

Investigators identified a highly conserved neutralizing epitope targeted by a broad-spectrum neutralizing antibody BA7535, which demonstrated high neutralization potency against not only previous variants, such as Alpha, Beta, Gamma, Delta and Omicron BA.1-BA.5, but also more recently emerged Omicron subvariants.