A Multidimensional Atlas of Human Glioblastoma-Like Organoids Reveals Highly Coordinated Molecular Networks and Effective Drugs

The authors used advanced human glioblastoma-like organoid, LEGO: Laboratory Engineered Glioblastoma-like Organoid, models and provided an unprecedented comprehensive characterization of LEGO models using single-cell transcriptome, DNA methylome, metabolome, lipidome, proteome, and phospho-proteome analysis.