Induced Pluripotent Stem Cell–Derived Exosomes Attenuate Vascular Remodelling in Pulmonary Arterial Hypertension by Targeting HIF-1α and Runx2

Investigators used murine iPSCs generated from mouse embryonic fibroblasts with triple factor transduction to determine the efficacy and action mechanism of iPSC-derived exosomes in attenuating PAH in rats with monocrotaline-induced pulmonary hypertension.