Oxidative Stress Accelerates Intestinal Tumorigenesis by Enhancing 8-Oxoguanine-Mediated Mutagenesis in MUTYH-Deficient Mice

Investigators explored the causal relationship between oxidative stress, somatic mutations in pre-tumor-initiated normal tissues, and tumor incidence in the small intestines of MUTYH-proficient and MUTYH-deficient mice.