Protective Effect of Secretory APE1/Ref-1 on Doxorubicin-Induced Cardiotoxicity via Suppression of ROS and p53 Pathway

Designated adenoviral preprotrypsin-leading sequence apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was used to overexpress secretory APE1/Ref-1 and assess its role in preventing doxorubicin-induced cardiomyopathy in vitro.