VEXAS Syndrome Is Characterized by Inflammasome Activation and Monocyte Dysregulation

Investigators studied a unique prospective cohort of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) patients. They showed that monocytes from VEXAS are quantitatively and qualitatively impaired and display features of exhaustion with aberrant expression of chemokine receptors.