SMARCAL1 Is a Dual Regulator of Innate Immune Signaling and PD-L1 Expression That Promotes Tumor Immune Evasion

The authors identified the SNF2-family DNA translocase SMARCAL1 as a factor that favored tumor immune evasion by a dual mechanism involving both the suppression of innate immune signaling and the induction of PD-L1-mediated immune checkpoint responses.