Pharmacological Modulation of RB1 Activity Mitigates Resistance to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer

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Scientists demonstrated that oxaliplatin induces RB1 phosphorylation, which is associated with the resistance to neoadjuvant oxaliplatin-based chemotherapy in locally advanced rectal cancer.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
Abstract