Epigenetic Drug Screening for Trophoblast Syncytialization Reveals a Novel Role for MLL1 in Regulating Fetoplacental Growth

Scientists conducted a systematic drug screen using an epigenetic compound library to systematically investigate the epigenetic mechanism essential for syncytialization, and identified mixed lineage leukemia 1 (MLL1), a histone 3 lysine 4 methyltransferase, as a crucial regulator of trophoblast syncytialization.