Manipulating Redox Homeostasis of Cancer Stem Cells Overcome Chemotherapeutic Resistance through Photoactivatable Biomimetic Nanodiscs

A nanotherapeutic strategy was developed using tumor-penetrating peptide iRGD-modified high-density lipoprotein-mimetic nanodiscs that ingeniously loaded with pyropheophorbide-a, bis (2-hydroxyethyl) disulfide, and camptothecin by synthesizing two amphiphilic drug-conjugated sphingomyelin derivatives.