ER Stress and Lipid Imbalance Drive Diabetic Embryonic Cardiomyopathy in an Organoid Model of Human Heart Development

Using an advanced human heart organoid system, researchers simulated embryonic heart development under pregestational diabetes–like conditions. These organoids developed pathophysiological features observed in mouse and human studies before, including reactive oxygen species-mediated stress and cardiomyocyte hypertrophy.