Chronic Hypoxia Impairs Skeletal Muscle Repair via HIF-2α Stabilization

Experimental mice were exposed to prolonged normobaric hypoxic air to establish a chronic hypoxia model. The impact of chronic hypoxia on body composition, muscle mass, muscle strength, and the expression levels of hypoxia-inducible factors HIF-1α and HIF-2α in muscle stem cell was examined.