Newsletters

[EMBO Molecular Medicine] Researchers identified telomeric DNA damage signaling as a driver of idiopathic pulmonary fibrosis, with targeted inhibition reversing key molecular and fibrotic features of disease.

[American Journal of Respiratory Cell and Molecular Biology] Scientists indicated that S100A2 is a key driver of epithelial dysfunction in lung fibrosis, promoting loss of alveolar type 2 epithelial (AT2) identity, aberrant basal fate acquisition, and persistent epithelial injury.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Investigators demonstrated that nuclear protein 1 (NUPR1) inhibition exacerbates iron accumulation, enhances lipid peroxidation, impairs mitochondrial function, disrupts cellular metabolism, and increases oxidative stress in lung epithelial cells.

[Cancer Letters] Researchers reported the novel finding that ubiquitin-specific protease 22 (USP22), a key regulator of protein ubiquitination and transcriptional activity, regulates mitochondrial protein expression, and oxidative phosphorylation.

[Expert Review of Molecular Diagnostics] The authors identified LINC00673 upregulation and the rs9914618 variant as potential biomarkers of lung squamous cell carcinoma risk and prognosis.

[Journal of Biological Chemistry] Investigators identified TRDMT1 (DNMT2), an m5C methyltransferase, as a tumor suppressor in LUAD. It was found that TRDMT1 expression is significantly lower in LUAD tissues, and this reduction is associated with poor prognosis in patients.

[Biochemical and Biophysical Research Communications] Scientists showed that Thioredoxin domain-containing (TXNDC)15 is downregulated in LUAD and predicts better survival. Functional assays revealed that TXNDC15 suppresses proliferation by inducing G2/M phase arrest.

[Nature Immunology] The authors highlight how distinct inflammatory programs work together within the fibrotic lung niche to drive the progression of idiopathic pulmonary fibrosis.

[Seminars in Cell & Developmental Biology] Researchers highlight how dysplastic basal-like cells emerge after severe lung injury, linking abnormal alveolar repair to failed regeneration and chronic lung disease progression.

[UCLA] Dr. Jie Deng of UCLA has received an American Cancer Society grant to study how radiation therapy and the immune system can work together to improve outcomes in non-small cell lung cancer.

[MicrobiotiX (BioSpace)] MicrobiotiX announced the successful completion of the sentinel cohort of its first-in-human Phase I clinical trial evaluating MP101 in patients with pneumonia caused by Pseudomonas aeruginosa.

[Nature] The US FDA granted approval to Moderna’s mRNA-based flu vaccine, mFLUSIVA, for adults aged 50–64, and accelerated approval for adults aged 65 and older.