The Ferroptosis Inhibitor NUPR1 Coordinates the Mitochondrial Response to Oxidative Stress and Cell Metabolism during COPD Pathogenesis in the Lung

Investigators demonstrated that nuclear protein 1 (NUPR1) inhibition exacerbates iron accumulation, enhances lipid peroxidation, impairs mitochondrial function, disrupts cellular metabolism, and increases oxidative stress in lung epithelial cells.