EPO Regulates the Differentiation and Homing of Bone Marrow Mesenchymal Stem Cells Through Notch1/Jagged Pathway to Treat Pulmonary Hypertension

Scientists investigated whether erythropoietin (EPO) can treat pulmonary arterial hypertension in rats by regulating the differentiation and homing of bone marrow MSCs (BMSCs) through Notch1/Jagged signaling pathway. BMSCs were treated with 500 IU/mL EPO, and the proliferation, migration, invasion, and differentiation ability, and the expression of MMP-2 and MMP-9 protein of BMSCs were detected in vitro.