Altered Erythropoiesis via JAK2 and ASXL1 Mutations in Myeloproliferative Neoplasms

Using primary myeloproliferative neoplasms samples and engineered embryonic stem cells, researchers demonstrated that mutations in JAK2 induce a significant increase in erythroid colony formation, whereas mutations in additional sex combs-like 1 (ASXL1) led to erythroid colony defect.