Synaptic Dysfunction and Extracellular Matrix Dysregulation in Dopaminergic Neurons from Sporadic and E326K-GBA1 Parkinson’s Disease Patients

Researchers investigated the electrophysiological properties, synaptic activity, and gene expression differences in dopaminergic neurons derived from iPSCs of healthy controls, sporadic Parkinson’s disease (PD) patients, and PD patients with E326K-GBA1 mutations.