Mechanically Tough, Adhesive, Self-Healing Hydrogel Promotes Annulus Fibrosus Repair via Autologous Cell Recruitment and Microenvironment Regulation

An innovative triple cross-linked oxidized hyaluronic acid-dopamine- polyacrylamide composite hydrogel, modified with collagen mimetic peptide and supplied with transforming growth factor beta 1 was developed for annulus fibrosus regeneration.