Sustained Antidepressant Effects of Ketamine Metabolite Involve GABAergic Inhibition-Mediated Molecular Dynamics in aPVT Glutamatergic Neurons

Researchers demonstrated that the sustained antidepressant-like behavioral effects of (2S,6S)-hydroxynorketamine in repeatedly stressed animal models involved neurobiological changes in the anterior paraventricular nucleus of the thalamus.