Boosting Cartilage Repair with Silk Fibroin-DNA Hydrogel-Based Cartilage Organoid Precursor

Researchers developed a novel RGD-SF-DNA hydrogel microsphere via a microfluidic system by integrating photopolymerization with self-assembly techniques and then modified with Pep-RGDfKA. In vitro studies demonstrated that RSD-MSs enhanced BMSCs proliferation, adhesion, and chondrogenic differentiation.