A Novel HDAC6 Inhibitor Interferes Microtubule Dynamics and Spindle Assembly Checkpoint and Sensitizes Cisplatin-Induced Apoptosis in Castration-Resistant Prostate Cancer

Cell proliferation was examined in CRPC PC-3 and DU-145 cells using sulforhodamine B assay and anchorage-dependent colony formation assay. Flow cytometric analysis of propidium iodide staining was used to determine cell-cycle progression.