CYP7B1-Mediated 25-Hydroxycholesterol Degradation Maintains Quiescence-Activation Balance and Improves Therapeutic Potential of Mesenchymal Stem Cells

Scientists demonstrated that CYP7B1 was the common critical molecule that promoted activation and impeded quiescence of bone marrow-MSCs under inflammatory stimulation. Mechanistically, CYP7B1 degraded 25-hydroxycholesterol (25-HC) into 7α,25-dihydroxycholesterol , which alleviates the quiescence maintenance effect of 25-HC through Notch3 signaling pathway activation.