CD_99 G1 Neutrophils Modulate Osteogenic Differentiation of Mesenchymal Stem Cells in the Pathological Process of Ankylosing Spondylitis

Single-cell RNA sequencing was used to identify cell populations and their gene signatures in the spinal enthesis of five patients with ankylosing spondylitis and three healthy individuals. The transcriptomes of 40 065 single cells were profiled and divided into 7 clusters: neutrophils, monocytic cells, granulomonocytic progenitor_erythroblasts, T cells, B cells, plasma cells and stromal cells.