Osr1-Mediated Mesothelial Transition of Liver Mesenchymal Cells Exacerbates Fibrotic Liver Damage

Single-cell RNA sequencing with in vivo lineage tracing in non-alcoholic steatohepatitismodel mice reveals a subpopulation of HSCs transitioning back to a state resembling their developmental precursors, mesothelial cells, after liver injury.