GTP Binding Protein 2 Maintains the Quiescence, Self-Renewal, and Chemoresistance of Mouse Colorectal Cancer Stem Cells via Promoting Wnt Signaling Activation

The authors characterized the expression and function of GTP binding protein 2 (GTPBP2) in a chemical-induced mouse colorectal cancer (CRC) model. They found that GTPBP2 was expressed at a higher level in CD133+CD44+ CCSCs compared with other CRC cells.