DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T Cell Immunity in Hepatocellular Carcinoma.

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Scientists showed that DNA of neutrophil extracellular traps binds transmembrane and coiled-coil domains 6 (TMCO6) on CD8+ T cells to impair anti-tumor immunity and thereby promote HCC progression. TGF-β1 induced NET formation, which recruited CD8+ T cells.
[Cancer Research]
Abstract