mTORC1 Hyperactivation and Resultant Suppression of Macroautophagy Contribute to the Induction of Cardiomyocyte Necroptosis by Catecholamine Surges

Researchers investigated the role of mechanistic target of rapamycin complex 1 (mTORC1) and potential underlying mechanisms in isoproterenol-induced cardiomyocyte necrosis.