Neuromuscular Organoids Model Spinal Neuromuscular Pathologies in C9orf72 Amyotrophic Lateral Sclerosis

With the C9orf72 ALS patient-derived iPSCs and isogenic controls, researchers used an neuromuscular organoid (NMO) system containing trunk spinal cord neural and peripheral muscular tissues to show that the ALS NMOs could model peripheral defects in ALS.