Targeting P2Y₁₄R Protects against Necroptosis of Intestinal Epithelial Cells through PKA/CREB/RIPK1 Axis in Ulcerative Colitis

Based on the over-expression of P2Y14R in the intestinal epithelium of mice with experimental colitis, investigators reported that male mice lacking P2Y14R in intestinal epithelial cells exhibited less intestinal injury induced by dextran sulfate sodium.