APOE4 Genotype and Aging Impair Injury-Induced Microglial Behavior in Brain Slices, including toward Aβ, through P2RY12

Using ex vivo confocal microscopy, scientists analyzed microglial dynamic behaviors in the entorhinal cortex and hippocampus CA1 of 6-, 12-, and 21-month-old mice APOE3 or APOE4 knock-in mice expressing GFP under the CX3CR1 promoter.