YTHDF2 Protein Stabilization by the Deubiquitinase OTUB1 Promotes Prostate Cancer Cell Proliferation via PRSS8 mRNA Degradation

With in vivo and in vitro ubiquitination assays, OUT domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) was shown to block ubiquitin transfer to YTH domain-containing family protein 2 (YTHDF2) independent of its deubiquitinase activity.