Differential In Vivo Roles of Mpl Cytoplasmic Tyrosine Residues in Murine Hematopoiesis and Myeloproliferative Disease

Investigators introduced mutations in the mouse germline and reported a consistent physiological requirement for Mpl-Y599, mutation of which resulted in thrombocytopenia, deficient megakaryopoiesis, low HSC number and function, and attenuated responses to myelosuppression.