Hypoxia-Induced TREM1 Promotes Mesenchymal-Like States of Glioma Stem Cells via Alternatively Activating Tumor-Associated Macrophages

Investigators showed that the triggering receptor expressed on myeloid cells-1 (TREM1) preferentially expressed by M2-like tumor-associated macrophages and induced glioma stem cells (GSCs) into mesenchymal-like states by modulating the secretion of TGFβ2, which activated the TGFβR/SMAD2/3 signaling in GSCs.