Tonic TCR and IL-1β Signaling Mediate Phenotypic Alterations of Naive CD4+ T Cells

Researchers identified that interleukin (IL)-1β signaling affects Inert naive CD4⁺ T (T_N)cell characteristics, independent of tonic T cell receptor signaling, which also altered T_N cell phenotypes. IL-1β reversibly attenuates the differentiation potential of T_N cells toward Treg cells.