Phenotypic Screen of 68 Colorectal Cancer Cell Lines Identifies CEACAM6 and CEACAM5 as Markers of Acid Resistance

Scientists reported pH-related phenotypes of 68 colorectal cancer cell lines by measuring i) extracellular acidification as a readout of acid production by fermentative metabolism and ii) growth of cell biomass over a range of extracellular pH levels as a measure of the acid sensitivity of proliferation.