A Subpopulation of Luminal Progenitors Secretes Pleiotrophin To Promote Angiogenesis and Metastasis in Inflammatory Breast Cancer

Using single-cell RNA sequencing, multiplex staining, and serum analysis in inflammatory breast cancer (IBC) patients, scientists identified enrichment of a subgroup of luminal progenitor cells containing high expression of the neurotropic cytokine pleiotrophin in IBC tumors.