DNAJB1-PRKACA Fusion Neoantigens Elicit Rare Endogenous T Cell Responses That Potentiate Cell Therapy for Fibrolamellar Carcinoma

Scientists defined endogenous CD8 T cell responses to a conserved DNAJB1-PRKACA gene fusion in fibrolamellar carcinoma patients and evaluate fusion-specific T cell receptors for use in cellular immunotherapies.