TGR5-Mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Circuit Regulates Depressive-Like Behavior in Male Mice

Using depression models of chronic social defeat stress and chronic restraint stress in male mice, researchers found that TGR5 in the lateral hypothalamic area predominantly decreased in GABAergic neurons, the excitability of which increased in depressive-like mice.
AbstractGraphical Abstract