Glucosylceramide Accumulation in Microglia Triggers STING-Dependent Neuroinflammation and Neurodegeneration in Mice

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Scientists investigated the mechanisms by which glucosylceramide (GC) accumulation induced neuroinflammation. They found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo.
[Science Signaling]
Abstract