CGRP Sensory Neurons Promote Tissue Healing via Neutrophils and Macrophages

Scientists showed that ablation of the NaV1.8 nociceptor impairs skin wound repair and muscle regeneration after acute tissue injury. Nociceptor endings grew into injured skin and muscle tissues and signal to immune cells through the neuropeptide calcitonin gene-related peptide (CGRP) during the healing process.