APP Antisense Oligonucleotides Reduce Aβ Aggregation and Rescue Endolysosomal Dysfunction in Alzheimer’s Disease

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Researchers found that antisense oligonucleotides targeting APP are an effective approach to reduce APP protein levels and rescue endolysosome and autophagy dysfunction in APP duplication human induced pluripotent stem cell-derived cortical neurons.
[Brain]
Abstract