SC912 Inhibits AR-V7 Activity in Castration-Resistant Prostate Cancer by Targeting the Androgen Receptor N-terminal Domain

Investigators discovered a small molecule, SC912, which bound to to full-length androgen receptor (AR) as well as AR-V7 through AR N-terminal domain (AR-NTD). This pan-AR targeting relied on the amino acids 507–531 in the AR-NTD.