Regulatory T Cells Expressing CD19-Targeted Chimeric Antigen Receptor Restore Homeostasis in Systemic Lupus Erythematosus

In an humanized mouse model of Systemic Lupus Erythematosus, a single infusion of Fox19CAR-Tregs restricts autoantibody generation, delayed lymphopenia and restored the human immune system composition in lymphoid organs, without detectable toxicity.