Prevented Cell Clusters’ Migration via Microdot Biomaterials for Inhibiting Scar Adhesion

Scientists constructed a microdot biomaterial system, which released functionalized polypeptides targeting mitochondria and promoting the influx of extracellular calcium ions under the inflammatory environment, thus inhibiting the expression of N-cadherin mediating cell-cell interaction, and promoting apoptosis of cluster fibroblasts, synergistically inhibiting the migration of fibroblast clusters at the site of tendon injury.