Inactivation of Kindlin-3 Increases Human Melanoma Aggressiveness Through the Collagen-Activated Tyrosine Kinase Receptor DDR1

Researchers demonstrated that kindlin-3 inactivation through knockdown or somatic mutations increased BRAFV600mut melanoma cells oncogenic properties via collagen-related signaling by decreasing cell adhesion and enhancing proliferation and migration in vitro, and by promoting tumor growth in mice.