Lineage-Tracing Hematopoietic Stem Cell Origins In Vivo to Efficiently Make Human HLF⁺ HOXA⁺ Hematopoietic Progenitors from Pluripotent Stem Cells

Guided by the arterial origins of blood, the authors efficiently and rapidly differentiate human pluripotent stem cells into posterior primitive streak, lateral mesoderm, artery endothelium, hemogenic endothelium, and >90% pure hematopoietic progenitors within ten days.