17β-Estradiol Protects Female Rats from Bilateral Oophorectomy-Induced Nonalcoholic Fatty Liver Disease Induced by Improving Linoleic Acid Metabolism Alteration and Gut Microbiota Disturbance

The combination of liver transcriptomics and metabolomics analysis revealed that linoleic acid (LA) metabolism, a pivotal pathway in fatty acids metabolism was mainly manipulated during the induction and treatment of nonalcoholic fatty liver disease.