Histone Methyltransferase Suv39h1 Regulates Hepatic Stellate Cell Activation and Is Targetable in Liver Fibrosis

The authors investigated the role of Suv39h1, a lysine methyltransferase, in HSC-myofibroblast transition and the implication in liver fibrosis. HSC-specific or myofibroblast-specifiSuv39h1 deletion was achieved by crossbreeding the Suv39h1 f/f mice to the Lrat-Cre mice or the Postn-CreERT2 mice.